参麦注射液防治奥沙利铂化疗所致毒性临床研究

The clinical research of Shenmai injection in prevention of oxaliplatin chemotherapy induced toxicity

目的研究参麦注射液在防治奥沙利铂化疗所致毒性的作用。方法将60例胃癌患者随机分成两组,每组30例。空白对照组,化疗单用奥沙利铂100mg/m2;实验组,奥沙利铂100mg/m2化疗同时给予参麦注射液80mL/d加入5%葡萄糖中静滴,每个患者完成4个周期化疗后参加评价。结果合用参麦注射液患者化疗后较单纯使用奥沙利铂化疗者免疫功能增强,神经毒性降低。结论参麦注射液可减轻奥沙利铂化疗所致毒性。

Objective To study the effect of Shenmai injection on prevention of oxaliplatin chemotherapy induced toxicity.Methods Sixty patients were randomly divided into two groups,30 cases in each group.Patients in control group were treated with oxaliplatin 100 mg/m2;patients in experimental group were given 100 mg/m2 of oxaliplatin with Shenmai injection 80 mL/d in 5% dextrose intravenous drip concurrently,each case was completed 4 cycles of chemotherapy after participating in the evaluation.Results Compared with control group,the immune function of patients in experimental group enhanced and the neurotoxicity of oxaliplatin reduced.Conclusion Shenmai injection can reduce oxaliplatin chemotherapy induced toxicity.