米非司酮联合米索前列醇在早孕及早期中孕引产的临床应用

The clinical application of mifepristone and misoprostol in labor induction of early pregnancy and early second-trimester

目的探讨米非司酮联合米索前列醇用于早孕及早期中孕引产的临床效果。方法选择本院2007年5月～2011年11月收治的320例孕妇,随机分为对照组和观察组,每组160例。对照组孕妇按照负压吸宫术的常规步骤进行手术,观察组孕妇采用米非司酮联合米索前列醇用于早孕及早期中孕引产,比较两组孕妇的产后子宫出血量以及流产疗效。结果观察组孕妇的产后子宫出血量为(138.00±10.10)mL,对照组出血量为(180.00±10.03)mL;观察组完全流产131例(81.88%),对照组完全流产100例(62.50%)。两组产后出血量及完全流产率比较差异有统计学意义(P<0.05)。结论采用米非司酮联合米索前列醇治疗早孕及早期中孕引产疗效确切,值得推广应用。

Objective To investigate clinical application of mifepristone and misoprostol in labor induction of early pregnancy and early second-trimester.Methods Three hundred and twenty women with pregnancy from May 2007 to November 2011 were randomly divided into control group and observation group,and 160 cases of each group.The control group was given the conventional vacuum aspiration of uterus surgery procedure while the observation group was given mifepristone and misoprostol for labor induction of early pregnancy and early second-trimester.Abortion bleeding volume and abortion efficacy were compared between the two groups.Results The abortion bleeding volume was （138.00±10.10） mL in the observation group,and（180.00±10.03） mL in the control group;the complete abortion rate of observation group was 81.88%,while the control group＇s was 62.50%.There were statistical differences between the two groups（P 0.05）.Conclusion Mifepristone and misoprostol for treating with labor induction of early pregnancy and early second-trimester is effective,and it should be widely applied in clinic.