儿童急性白血病G-CSF自身抗体及其对G-CSF血清浓度的影响

Occurrence of therapy induced autoantibodies to G CSF and their influence on serum G CSF concentration in children with acute leukemia

目的 研究急性白血病患儿应用 rh G- CSF后自身抗体的产生及对 G- CSF血清浓度的影响。方法 应用 EL ISA技术检测 4 6例急性白血病患儿和 10 4例正常儿童。结果 11例应用rh G- CSF的急性白血病患儿检测到自身抗体。结论 G- CSF自身抗体的产生与 rh G- CSF剂量和疗程无关 ,且不显著地降低 G- CSF血清浓度。 rh G- CSF临床应用具有安全性。

Objective To investigate the occurrence of autoantibodies after using rhG CSF in children with acute leukemia and their influence on serum G CSF concentration.Methods Blood samples collected from 46 patients with acute leukemia and 104 normal children were measured with ELISA technique.Results Autoantibodies were detected in 11 children with acute leukemia.Conclusions The occurrence of G CSF autoantibodies have no significant relationship to rhG CSF doses and courses,and have no influence on serum G CSF concentration.Clinical application of rhG CSF is safety.