二阶导数光谱法测定尿中氧氟沙星排泄量

DETERMINATION OF OFLOXACIN EXCRETION IN URINE BY SECOND DERIVATIVE SPECTROPHOTOMETRY

目的 :在 6例健康受试者中进行国产氧氟沙星片药代动力学研究。方法 :采用二阶导数光谱法测氧氟沙星尿药浓度。结果 :药动学参数分别为 :K =0 1343h 1;T1/ 2 =5 40h ;Xu0～ 2 4 =16 2 35mg ;排泄率 (Q % ) =81 2 4%。结论 :方法简便、快捷 。

OBJECTIVE:To study the pharmacokinetics characteristics of Ofloxacin (Chengdu, China) tablet in 8 Chinese healthy volunteers . METHODS:Determination of drug concentration in urine by second derivative spectrophotometry was estabilished. RESULTS:K=0.1343 h 1 ;T 1/2 = 5.40 h;Xu 0～24 =162.35 mg;Q%=81.24%. CONCLUSION:This method was simple, rapid;It was suitable for phamacokinetic study.