伴胸腺瘤重症肌无力的临床特点(附96例分析)

Clinical characteristics of myasthenia gravis in patients with thymoma

目的 研究伴胸腺瘤重症肌无力的临床特点。方法 对经手术病检证实的 96例MG伴胸腺瘤患者的临床资料进行回顾性分析 ,并采用 χ2 检验及t检验与 114 9例经影像学检查无胸腺瘤表现的MG患者进行比较。结果 胸腺瘤组男性发病者多 (男∶女 =1 82∶1) ,且多于 30岁后发病 (71 9% ) ,以肢体无力和延髓症状首发者多见 (4 3 8% ) ,按改良Os serman分型 ,以Ⅲ型和Ⅳ型为主 (4 5 8% ) ,危象发生率高 (38 5 % ) ,病死率高 (8 3 % )。结论 伴胸腺瘤的重症肌无力有其独特临床特点 。

Objective To study the clinical characteristics of myasthenia gravis(MG) with thymoma. Methods Retrospective study was done on 96 MG patients with thymoma who were diagnosed by pathological examination. The χ2 test and t test were used to evaluate the difference of clinical manifestations between MG patients with and without thymoma. Results MG patients with thymoma were more likely to be male (male to female, 182∶1) and had disease onset after 30 years of age. Limbs and bulbar muscles were more frequently involved as the first symptom in the patients with thymoma. According to modified Ossermans criteria, 44 patients (45.8%) were classified in group Ⅲ and Ⅳ. The rate of myasthenia crisis and of mortality in patients with thymoma were higher than patients without thymoma. Conclusions MG associated with thymoma had its own clinical characteristics, which was helpful for the diagnosis and treatment.