环磷酰胺联合环孢菌素A对急性百草枯中毒预后的影响

Effect of cyclophosphamide combined with cyclosporine A on the prognosis of acute paraquat poisoning

目的研究环磷酰胺联合环孢菌素A对急性百草枯中毒患者预后的影响。方法对2007年7月至2011年6月收治的急性百草枯中毒患者的临床资料进行回顾性研究，将常规治疗患者作为对照组，将环磷酰胺联合环孢菌素A组作为治疗组，观察百草枯患者的存活时间、丙二醛（MDA）浓度、呼吸衰竭时间、肺纤维化发生时间、多器官功能障碍综合征（MODS）发生时间、白细胞计数、中心粒细胞计数。结果治疗组患者较对照组患者存活时间延长，MDA浓度降低，呼吸衰竭、肺纤维化及MODS平均发生时间延长，白细胞及中心粒细胞计数降低，差异有统计学意义（P〈0．05）。结论环磷酰胺联合环孢菌素A治疗能明显改善百草枯中毒患者的预后，延长存活时间。

Objective To study the influence of cyclophosphamide combined with cyclosporin A on the prognosis of patients with acute paraquat poisoning. Methods The clinical data of patients with acute paraquat poisoning from July 2007 to June 2011 were retrospectively studied. The patients recieved conventional treatment as control group, the patients recieved cyclophosphamide combined with cyclosporin A as treatment group. The survival time, concentration of MDA, respiratory failure time, pulmonary fi- brosis time, MODS time, white blood cell count, neutrophil count were observed. Results Compared with the control group in the treatment group, the survival time was longer, MDA concentration was low- er, average occurrence time of respiratory failure time, pulmonary fibrosis time and MODS were longer, white blood cell and neutrophil counts were lower, and the differences were significant （P 〈 0.05 ）. Conclusions Cyclophosphamide combined with cyclosporin A therapy can significantly improve the prognosis of patients with paraquat posioning and prolong the survival time.