三种骨质疏松症筛检方法的效果评价

Comparison of Different Kinds of Screening Tools for Osteoporosis

目的通过比较与评价不同骨质疏松筛检的方法 ,为我国绝经期妇女人群的简易筛检方法提供数据支持。方法 282名已经通过双能X线骨密度仪检测的绝经期妇女,采用骨质疏松风险估计简单计算法(SCORE)、骨质疏松风险评估工具(ORAI)、亚洲人群骨质疏松自我评价(OSTA)三种不同的简易方法进行筛检,计算相应的评价指标,探讨三种方法筛检本次研究人群的效果。结果经过不同计算公式得到的SCORE法、ORAI法及OSTA法的AUC值分别为:0.657、0.686和0.681,SCORE法的灵敏度为0.965,OSTA法的特异度为0.951。结论使用单一的方法来筛检该人群的AUC值均不高;但SCOR法的灵敏度比较高,适合阳性人群的筛检;OSTA法的特异度比较高,适合阴性人群的筛检。

Objective The aim of this study is to evaluate different kinds of techniques and their ability to act as screening tools which are used for Northern women of our country . Methods We selected a group of 282 postmenopausal women who had underwent dual energy X-ray absorptiometry,then different screening tools for osteoporosis like SCORE, ORAI and OSTA were used to screen these women. The sensitivity and specificity along with the areas under the receiver-operating characteristic curves were calculated to access the performance. Results The results showed that different tools were not suitable for selecting Northern women of our country solely because of the low AUC. But the sensitivity of SCORE was 0. 965 and the specificity of OSTA was 0. 951,which were ex- cellent enough for selecting osteoporosis and non-osteoporosis separately. Conclusion By comparing the overall index of different tools,SOCRE and OSTA are suggested to be taken together and applying them will result in more prudent use of BMD technology.