益气活血剂对阿霉素肾病模型的影响

Effects of Herbs for Replenishing Qi and Promoting Blood Flow on Adriamycin-Induced Nephrotic Syndrome Rat Model

为探讨益气活血剂治疗肾病综合征的作用机理 ,采用盐酸阿霉素成功复制出大鼠肾病模型 ,随机分为 4组 ,每组 10只 ,分别为正常对照组、模型对照组、强的松治疗组、强的松加益气活血剂治疗组。用药8周后 ,选取血液流变学、血清白蛋白、总蛋白、血液自由基 3项、组织自由基 3项作为观察指标。结果 :强的松加益气活血剂治疗组与模型对照组比较 ,绝大部分指标有改善 (P <0 .0 5或P <0 .0 1) ;与强的松治疗组比较 ,血清白蛋白 (A)、超氧化物歧化酶 (SOD)及血液流变学指标均有显著性差异 (P <0 .0 5或P <0 .0 1)。结果表明 :大鼠肾病综合征模型血液呈高凝状态 ,抗氧化能力下降 ,氧自由基增加 ;

To study the effect of herbs for replenishing qi and promoting blood flow (HRP) on nephrotic syndrome, the nephrotic syndrome rat model was established by hydrochloric acid adriamycin. Forty rats were randomly allocated to 4 groups:group A(n=10), normal control group;group B(n=10),rat model without treatment; group C(n=10), rat model treated with prednisone; group D (n=10), rat model treated with prednisone and HRP. Blood rheology, serum albumin, serum total protein, blood free radical and tissue free radical were determined after 8 weeks. Results showed that compared with group C, group D is good for decreasing blood viscosity, increasing serum protein and anti-oxidation ability (P< 0.01 ～ 0.05 ). It is concluded that HRP can decrease the high blood viscosity and counteract the damage of oxygen free radical in the nephrotic syndrome rat model.