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神经降压素及其受体1与乳腺癌 被引量：1

Neurotensin and its receptor 1 in breast cancer
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摘要 神经降压素是一种分布于脑和胃肠道的多肽,具有广泛的中枢和外周效应。近来研究表明神经降压素及其1型受体的信号与乳腺癌的增殖、抗凋亡、侵袭转移方面具有密切的联系;而神经降压素受体1仅在乳腺癌中表达将为开发神经降压素类似物为基础的新型肿瘤显像剂及靶向治疗药物提供广泛的应用前景,有助于乳腺癌的早期诊断和治疗。 Neurotensin is a polypeptide,distributed mainly in the brain and the gastrointestinal tract.It has a wide range of central and peripheral effects.Recent studies indicate that the signal of neurotensin and neurotensin receptor 1 is closely associated with proliferation,anti-apoptosis,invasion,and metastasis of breast cancer.The fact that high expression of neurotensin receptor 1 in breast cancer may provide a great potential to exploit new tumor imaging agents based on neurotensin analogues or neurotensin receptor-targeted therapeutic drugs,which may contribute to the early diagnosis and therapy in breast cancer.
作者 张同先 牛昀 张巍
机构地区 天津医科大学附属肿瘤医院乳腺病理研究室
出处 《国际病理科学与临床杂志》 CAS 2012年第2期145-149,共5页 Journal of International Pathology and Clinical Medicine
基金 国家自然科学基金(30872519)~~
关键词 乳腺癌 神经降压素 神经降压素受体1 breast cancer neurotensin neurotensin receptor 1
分类号 R737.9 [医药卫生—肿瘤]
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参考文献22

  • 1Mustain WC, Rychahou PG, Evers BM. The role of neurotensin in physiologic and pathologic processes current opinion in endocrinology[J]. Curr Opin Endocrinol Diabetes Obes, 2011, 18 (1):75-82.
  • 2Evers BM. Neurotensin and growth of normal and neoplastic tissues[J]. Peptides, 2006, 27(10):2424-2433.
  • 3Carraway RE, Plona AM. Involvement of neurotensin in cancer growth: Evidence, mechanisms and development of diagnostic tools[J]. Peptides, 2006, 27(10):2445-2460.
  • 4Alshoukr F, Prignon A, Brans L, et al. Novel DOTA-neurotensin analogues for 111In scintigraphy and 68Ga PET imaging of neurotensin receptor-positive tumors[J]. Bioconjug Chem, 2011, 22(7):1374-1385.
  • 5Zhang K, An R, Gao Z, et al. Radionuclide imaging of small- cell lung cancer (SCLC) using 99mTc-labeled neurotensin peptide 8-13[J]. Nucl Med Biol, 2006, 33(4):505-512.
  • 6Heakal Y, Kester M. Nanoliposomal short-chain ceramide inhibits agonist-dependent translocation of neurotensin receptor 1 to structured membrane microdomains in breast cancer cells[J]. Mol Cancer Res, 2009, 7(5):724-734.
  • 7Myers RM, Shearman JW, Kitching MO, et al. Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors[J]. ACS Chem Biol, 2009, 4(7):503- 525.
  • 8Dupouy S, Mourra N, Doan VK, et al. The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers[J]. Biochimie, 2011, 93(9):1369-1378.
  • 9Wang JG, Li NN, Li HN, et al. Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-I and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1 [J]. Neuropeptides, 2011, 45(2):151-156.
  • 10Mazella J. Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking? [J]. Cell Signal, 2001, 13(1):1-6.

二级参考文献87

  • 1Laviola L, Natalicchio A, Giorgino F. The IGF-I signaling pathway [J]. Curt Pharm Des, 2007,13(7) :663-669.
  • 2Dearth RK, Cui X, Kim H J, et al. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2[ J]. Cell Cycle, 2007,6(6) :705-713.
  • 3Rother KI, Accili D. Role of insulin receptors and IGF receptors in growth and development [ J ]. Pediatr Nephrol, 2000,14 (7) :558- 561.
  • 4Sun X J, Rnthenberg P, Kahn CR, et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein [ J ]. Nature, 1991,352 (6330) :73-77.
  • 5Sesti G, Federici M, Hribal ML, et al. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders [ J ]. FASEB J, 2001, 15 (12) :2099-2111.
  • 6Kaburagi Y, Okochi H, Satoh S, et al. Role of IRS and PHIP on insulin-induced tyrosine phosphorylation and distribution of IRS proteins[J]. Cell Struct Funct, 2007,2( 1 ) :69-78.
  • 7Bjornholm M, He AR, Attersand A, et al. Absence of functional insulin receptor substrate-3 ( IRS-3 ) gene in humans [ J ]. Diabetologia, 2002,45 ( 12 ) : 1697-1702.
  • 8Cuevas EP, Escribano O, Chiloeches A, et al. Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation [ J ]. J Hepatol, 2007,46 ( 6 ) : 1089-1098.
  • 9Cai D, Dhe-Paganon S, Melendez PA, et al. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5 [ J ]. J Biol Chem, 2003, 278(28):25323-25330.
  • 10White MF. IRS proteins and the common path to diabetes[J]. Am J Physiol Endocrinol Metab, 2002,283 (3) :E413-422.

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国际病理科学与临床杂志
2012年 第2期

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