EAG1钾离子通道与肿瘤

EAG1 potassium channel and tumor

EAG1(ether-à-go-go-1)是电压依赖性钾离子通道家族成员。EAG1主要表达于脑组织中,在成肌细胞、睾丸、肾上腺及胎盘中有少量表达。近年来大量的研究提示EAG1选择性表达于多种组织来源的肿瘤中,而在相应的正常组织中未见表达,且与肿瘤的增生、恶化、侵袭、转移、复发、预后密切相关。这为肿瘤的诊断、预后评估和肿瘤的靶向治疗提供了一个新的特异性分子标志。

EAG1（ether-à-go-go-1）,a member of the voltage-dependent potassium channel family,is expressed mainly in the brain,slightly in placenta,testis,and adrenal gland,and transiently in myoblasts.Recently,several studies have suggested that EAG1 is selectively expressed in various tumor tissues.EAG1 plays an important role in tumor proliferation,malignant transformation,invasion,metastasis,recurrence and prognosis.Therefore,it provided a new,specific molecular target for the tumor diagnosis,prognosis evaluation and tumor-targeted therapy.