牛病毒性腹泻病毒非结构蛋白NS3的研究进展

Advance in Nonstructural Protein NS3 of Bovine Viral Diarrhea Virus

非结构蛋白NS3是致细胞病变型牛病毒性腹泻病毒的分子标记蛋白,它具有多种生物学功能。研究结果表明,NS3在病毒非结构蛋白的加工、成熟、基因组复制与转录过程中以及宿主细胞致细胞病变效应的产生中起重要作用。文章总结了NS3的生物学特性及其相关功能,为阐明NS3的致细胞病变作用机理奠定基础。

Nonstructural protein NS3 is considered a molecular marker for the cytopathic biotype of bovine viral diarrhea vi- rus and has a variety of biological functions. It has been reported that NS3 played an important role in the processing of other nonstructural proteins, the release of mature particles, viral RNA replication, transcription and the generation of cytopathic effect in the host cell. This paper summarizes the biological properties of NS3 and its related functions, which lays the founda tion for further study on the mechanism of NS3 induced cytopathic effect.