厚果鸡血藤种子中的一个新异戊烯基查耳酮(英文)

A new prenylated chalcone from the seedsof Millettia pachycarpa

目的:研究厚果鸡血藤种子的化学成分。方法:采用硅胶、MCI等多种层析柱分离手段.运用NMR和MS等波谱技术鉴定化合物的结构。结果:从厚果鸡血藤种子中分离并鉴定了4个黄酮类化合物:3-hydroxy-4-methoxylonchocarpin(1),4-methoxylonchocarpin(2),isobavachromene(3),dorspoinsettifolin(4)。结论:化合物1为新的查耳酮,化合物2-4为首次从该属植物中分离得到;化合物1-4对测试的部分细胞株显示了中等的抑制活性。

AIM：To investigate the chemical constituents from the seeds of Millettia pachycarpa.METHODS：The compoundswere isolated and purified by repeated column chromatography.Their structures were elucidated on the basis of spectroscopic analyses,and their cytotoxic activities against human tumor cell lines（7860,A549,A2780,Hela,K562） and murine tumor cell lines（LL/2,B16）were evaluated by MTT assay.RESULTS：Four flavonoids were obtained and their structures were identified as3-hydroxy-4-methoxylonchocarpin（1）,4-methoxylonchocarpin（2）,isobavachromene（3）,and dorspoinsettifolin（4）.CONCLUSION：Compound 1 is a new prenylated chalcone,and compounds 2-4 were isolated from this genus for the first time.Compounds 1-4 selectivelyshowed moderate inhibition against one or more of the tested cell lines.