替勃龙联合高压氧治疗更年期综合征的临床效果

Clinical efficacy of tibolone combined with hyperbaric oxygen in treatment of menopausal syndrome

目的:探讨替勃龙联合高压氧治疗更年期综合征的临床效果。方法:将96例更年期综合征患者随机分为实验组(50例)和对照组(46例),实验组采取替勃龙联合高压氧治疗,对照组单独采用替勃龙治疗,疗程均为30天,治疗前后分别对两组患者进行Kupperman评分、焦虑自评量表(SAS)和抑郁自评量表(SDS)评分,放射免疫法检测血清雌二醇(E2)、促卵泡生成激素(FSH)和促黄体生成激素(LH)的水平。结果:两组患者治疗后Kupperman评分、SAS评分和SDS评分均低于治疗前,差异有统计学意义(P<0.05),且治疗后实验组各评分均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清E2水平均高于治疗前,血清FSH和LH水平则低于治疗前,差异均有统计学意义(P<0.05),且实验组血清E2上升程度以及FSH和LH下降程度均比对照组高,差异均有统计学意义(P<0.05)。结论:替勃龙联合高压氧治疗更年期综合征,可以有效改善患者血清相关激素水平,从而有效减轻更年期综合征症状,尤其是焦虑和抑郁症状,为更年期综合征拓展新的有效治疗途径,具有良好的社会效益。

Objective：To explore the clinical efficacy of tibolone combined with hyperbaric oxygen in treatment of menopausal syndrome. Methods：Ninety-six patients with menopausal syndrome were randomly divided into experimental group（50 cases） and control group（46 cases）,the patients in experimental group were treated with tibolone combined with hyperbaric oxygen,while the patients in control group were treated with tibolone,the courses of treatment in the two groups were 30 days,Kupperman scale,self-rating anxiety scale（SAS）,and self-rating depression scale（SDS） were conducted in the two groups before and after treatment,radioimmunoassay was used to detect serum levels of estradiol,follicle-stimulating hormone（FSH）,and luteinizing hormone（LH）. Results：Kupperman score,SAS score,and SDS score in the two groups after treatment were significantly lower than those before treatment（P0.05）;Kupperman score,SAS score,and SDS score after treatment in experimental group were significantly lower than those in control group（P0.05）.The serum levels of estradiol in the two groups after treatment were significantly higher than those before treatment,while the serum levels of FSH and LH in the two groups after treatment were significantly lower than those before treatment（P0.05）.The degree of increase of serum estradiol and the degrees of decrease of serum FSH and LH in experimental group were significantly higher than those in control group（P0.05）. Conclusion：Tibolone combined with hyperbaric oxygen used for the patients with menopausal syndrome can improve the serum levels of relevant hormones and relieve the symptoms of menopausal syndrome effectively,especially anxiety and depression,which become to be a new and effective method for treatment of menopausal syndrome,and it has good social benefits.