阿司匹林包合物的拉曼光谱和红外光谱研究

Research about aspirin inclusion by Raman spectroscopy and infrared spectroscopy

目的:通过拉曼光谱和红外光谱法分析阿司匹林包合物,探索拉曼光谱法作为一种新的验证包合物形成方法的可行性。方法:通过共聚焦拉曼光谱仪和傅里叶红外光谱仪分别测定并获得β-环糊精、阿司匹林、β-环糊精和阿司匹林物理混合物、阿司匹林包合物的拉曼图谱和红外图谱并将其进行对照分析。结果:在红外图谱和拉曼图谱中,阿司匹林的一些特征峰在其包合物中发生了位移,部分峰强发生变化甚至消失。结论:拉曼光谱和红外光谱同时表明,阿司匹林通过氢键作用嵌入β-环糊精的疏水空腔形成了包合物,其苯环结构、羰基结构和酯基结构被包裹于β-环糊精的空腔结构中。

Objective：To identify the formation of the inclusion compound of aspirin by the confocal Raman spectroscopy and infrared spectroscopy in order to decide the ability of the Raman spectroscopy as a new and simple method in identifying the inclusion compound.Methods：To obtain the Raman spectrum and infrared spectrum of aspirin,β-cyclodextrin,β-cyclodextrin and aspirin physcal mixture,aspirin-beta-cyclodextrin inclusion compound in the solid state with confocal Raman spectrometer and Fourier transform infrared spectrometer,and then was compared with each other and to reveal the structural features.Results：Marker bands of aspirin were shifted or weakened,ever dispeared in both IR and Raman spectrums.Conclusion：IR and Raman spectrum both indicated that the aspirin inclusion compound is formed via hydrogen bonds,and benzene ring,carbonyl group and ester group were included in the cavity of β-CD.