摘要
为寻找新型肝靶向抗癌前药,将具有肝靶向特征的天然分子甘草次酸的半合成衍生物与抗癌药环磷酰胺的活性代谢物氮芥磷酰二氯偶联制成11-脱氧甘草次酸类两个目标化合物和7个中间体。化合物的化学结构用常规光谱分析法进行鉴定,对合成工艺、理化性质和光谱特征进行系统描述。本研究对甘草次酸类新型肝靶向抗癌前药的药理活性筛选奠定基础。
To obtain new anticancer prodrugs on the bases of hepatocell targeting property of natural product glycyrrhetinic acid and its semi-synthetic derivatives, we prepared two conjugated products by the route of coupling 11-deoxo-glycyrrhe- tinic acid derivatives with nitrogen mustard dichlorophosphate （the active metabolite of anticancer drug cyclophospha- mide）. The structure of two target compounds and 7 intermediate products was characterized by routine spectrometric methods ;the technologies of preparation and physical-chemical properties were studied. This work may provide substan- tial bases for further pharmacological screening of new anticancer products from glycyrrhetinic acid derivatives with hep- directinz potency.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2012年第5期648-652,共5页
Natural Product Research and Development
基金
国家自然科学基金项目(30960461)
