2005-2010年鲍氏不动杆菌耐药趋势分析

Trend of drug resistance of Acinetobacter baunannii 2005-2010

目的了解鲍氏不动杆菌感染及耐药性变迁情况,探讨其发生的危险因素,并为临床提供预防治疗措施。方法对2005-2010年某医院临床标本中分离出的802株鲍氏不动杆菌进行耐药趋势分析。结果共分离鉴定鲍氏不动杆菌802株,分离率为4.74%;分离率最高的科室是呼吸内科,占43.52%;标本来源以呼吸道为主,占66.33%;鲍氏不动杆菌对15种抗菌药物耐药现象严重,耐药率逐年上升。结论某医院鲍氏不动杆菌的分离率及耐药性呈逐年增加的趋势,必须加强抗菌药物合理使用的管理,加强消毒隔离及手卫生,防止和减少耐药菌医院感染。

OBJECTIVE To understand the antimicrobial resistance of Acinetobacter baumannii,explore the risk factors for A.baumannii infections so as to provide basis for clinical prevention and treatment.METHODS A total of 802 strains of A.baumannii isolated from clinical specimens from 2005 to 2010 were collected,the trend of the drug resistance of those strains was analyzed.RESULTS Totally 802 strains of A.baumannii were isolated and identified with the isolation rate of 4.74%;the isolates were mainly isolated from the department of respiratory medicine,accounting for 43.52%;the respiratory tract was the major specimens source,accounting for 66.33%;the drug susceptibility testing results revealed that the drug resistance of A.baumannii to 15 antibiotics was serious and the drug resistance rates increased year by year.CONCLUSION The antimicrobial resistance rates and the isolation rates of A.baumannii are increasing year by year,it is necessary to strengthen the reasonable use of antibiotics and intensify the disinfection separation and hand hygiene so as to prevent and reduce the nosocomial infections.