贝尼地平和缬沙坦联合治疗对高血压病患者肾功能的影响

Influence of Benidipine and Valsartan combination therapy on renal function of patients with hypertension

目的探讨贝尼地平、缬沙坦单独治疗和联合治疗对高血压病患者肾脏的影响。方法将140例高血压病患者分为三组:A组(口服贝尼地平4 mg)、B组(口服缬沙坦80 mg)、C组(口服贝尼地平4 mg和缬沙坦80 mg)。疗程24周,观察治疗前后血压和肾功能的变化。结果 C组降低血压和降低尿蛋白排泄的幅度优于A、B组(P<0.01),治疗后肾小球滤过率在C组及A、B组之间,差异有高度统计学意义(P<0.01)。结论贝尼地平、缬沙坦长期单独治疗均可减少蛋白尿,保护肾脏,两药联合治疗对减少蛋白尿、保护肾脏有一定协同作用。

Objective To investigate the influence of Benidipine and Valsartan monotherapy and combination therapy on the renal function of patients with hypertension.Methods 140 patients with hypertension were randomly divided into three groups： group A（oral administration of 4 mg of Benidipine）,group B（oral administration of 80 mg of Valsartan） and group C（oral administration of 4 mg of Benidipine and 80 mg of Valsartan）.After 24 weeks of treatment,the changes of blood pressure and renal function before and after treatment were observed.Results The group C was superior to group A and B in the reduction of blood pressure and urinary protein excretion（P 0.01）.After treatment,the glomerular filtration rate was different among group C with group A and B,with statistical significance（P 0.01）.Conclusion Long-term Benidipine and Valsartan monotherapies can both reduce proteinuria and protect the kidneys.The combination therapy has certain synergistic effect on the reduction of proteinuria and protection of kidneys.