CRRT治疗MODS伴AKI患者临床研究

Clinical research on CRRT in MODS patients with AKI

目的探讨连续性肾脏替代治疗(CRRT continuous renal replacement therapy)在抢救多器官功能障碍综合征伴急性肾损伤患者的疗效。方法采用连续性静脉-静脉血液滤过(CVVH)治疗多器官功能障碍综合征急性肾损伤(AKI)患者46例。结果 CRRT治疗组中27例患者治愈,治疗后血肌酐、尿素氮明显下降,钾(K+)、钠(Na+)、动脉血氧饱合度(SaO2)、、PH值等基本恢复正常(P<0.01),血清细胞炎症因子hs-CRP、TNF-α、IL-6、IL-8明显下降(P<0.01)。结论连续性肾脏替代治疗能有效纠正水、电解质、酸碱紊乱,改善生命体征,排出尿毒素,清除炎症因子且能有较维持血流动力学的稳定,对于治疗多器官功能障碍综合征伴急性肾损伤是较为有效的治疗方法。

【Objective】 To investigate the effect of CRRT in treatment of multiple organ dysfunction patients with acute kidney injury.【Methods】 The continuous venovenous hemofiltration（CVVH） in treatment of 46 cases of multiple organ dysfunction patients with acute kidney injury.【Results】 27 patients cured,after treatment serum creatinine,blood urea nitrogen decreased,K＋,Na＋,CO2CP,SaO2,PH value et al,basic return to normal（P 〈0.01）,serum inflammatory cytokines hs-CRP,TNF-α,IL-6,IL-8 decreased significantly.【Conclusion】 The CRRT can effectively correct the water,electrolyte,acid-base disorders,to improve the vital signs,discharge urine toxin,removal of inflammatory cytokines and have a stable hemo-dynamics,effective treatment for multiple organ dysfunction with acute kidney injury.