老年抑郁症患者认知功能损伤影响因素的调查研究

Investigation of influence factors of cognitive function impairment of elderly patients with depression

目的探讨老年抑郁发作患者认知功能损伤情况及相关因素对抑郁症认知功能损伤的影响。方法选择2008年8月-2011年10月我院心理科门诊或住院的40例疗效差的抑郁症（疗效为进步和无效，观察组）和40例疗效好的抑郁症（疗效为痊愈和显著进步，对照组）病例进行回顾性对照研究，对患者以SDS、DIS、SSRS、FAA、FIC、SOB及得克萨斯社会行为问卷（TSBIA）、补充综合问卷等为工具进行随访观察。结果观察组家族史、适应状况、性格、家庭成员关系、抑郁类型、合并精神病性症状、发作次数、发病年龄、焦虑／躯体化和认识障碍等因素与对照组比较，差异有统计学意义（P〈0．05）；逐步回归分析显示，DIS、FAA、SDS、FIC、SOB、SSRS及TSBIA是与抑郁症认知功能损伤相关的独立因素（P〈0．05）。结论抑郁症患者存在认知功能障碍，心理社会因素对老年抑郁症患者的康复有明显影响。

Objective To explore the cognitive function impairment situation of elderly patients with depression and the influence of related factors to cognitive function impairment. Methods 40 cases of depression patients with poor effects （curative effect of progress and invalid, observation group） and 40 cases with good curative effects （curative effect of recov- ery and remarkable improvement, control group） in our out-patient clinic or hospital were selected from August 2008 to October 201 l, and a retrospective control study was carried ont. The patients were all followed up by tools of SDS, DIS, SSRS, FAA, FIC, SOB, Texas social behavior questionnaire （TSBIA）, addition comprehensive questionnaires. Results The difference of family history, the adapt situation, character, family members relations, depression type, combination of psychiatric symptoms, attack frequency, onset ages, anxiety/somzatization and cognitive barrier of the two groups were com- pared, and the differences were statistically significant （P 〈 0.05）; Stepwise regression analysis showed that DIS, FAA, SDS, FIC, SOB, SSRS and TSBIA were independently factors associated with cognitive function impairment （P 〈 0.05）. Conclusion The patients with depression all have cognitive dysfunction, the psychological and social factors obviously in- fluence on the recovery of elderly patients with depression.