广州管圆线虫病治疗药物筛选报告

Screening of Drugs against Angiostrongylus cantonensis

[目的 ]筛选治疗广州管圆线虫病的有效药物。[方法 ]以大白鼠为动物模型 ,人工感染广州管圆线虫第 3期幼虫后分别用伊维菌素、阿苯哒唑、甲苯咪唑和噻嘧啶进行治疗 ,然后解剖检虫、计数、测量 ,用 SPSS统计软件包分析比较 4种药物的疗效。 [结果 ]剂量为 2 0 mg/ kg.d× 6的阿苯哒唑和甲苯咪唑均能完全清除感染鼠体内的广州管圆线虫幼虫 ,而总剂量为 2 8mg/ kg的伊维菌素和 86 0 mg/ kg的噻嘧啶未能使感染鼠的虫数减少 ,也不影响第 1期幼虫的产出时间。 [结论 ]阿苯哒唑和甲苯咪唑对广州管圆线虫幼虫有显著的杀虫效果 ,伊维菌素和噻嘧啶无效。

Objective] To screen drugs against Angiostrongylus cantonensis. [Methods] 50 rats were infected with the infective laevaeof A. cantonensis and on the 7th day cured by Ivermectin, Mebendazole, Albendazole, Pyranteli pamoatis respectively in 4 groups. On differentdays after infection the rats were dissected and the worms were counted and measured. The data were analyzed by SPSS package.[Results] Albendazole and Mebendazole at dose of 20mg/kg.d for 6 days could eliminate the parasites in rats completely. However, Ivermectin orPyranteli pamoatis couldn't. [Conclusion] The effects of Albendozole andMebendazole against A. cantonensis are significant. Ivermectin andPyranteli pamoatis are ineffective to A. cantonensis.