不同证型老年女性高血压病患者性激素相关调控因素的比较研究

Comparative Study on Related Regulating Factors of Sex Hormones in Old Female with Different Syndromes of Hypertension

目的:探讨女性老年人高血压病肾气亏虚证、肝火上炎证与性激素相关调控因素的关联性,从而为研究老年人高血压病肾气亏虚证、肝火上炎证证候表现的病理生理基础提供依据。方法:根据高血压诊断与分级标准、中医辨证标准选择了女性高血压病肾气亏虚证、肝火上炎证患者各30例和健康老年女性30例,采用酶联免疫吸附法检测白介素-2(IL-2)、瘦素(Leptin)、肿瘤坏死因子(TNF-α)、促性腺激素释放激素(GnRH)和硫酸脱氢表雄酮(DHEA-S)的水平。结果:女性老年人高血压肾气亏虚证患者的性激素相关调控因素水平的异常变化与女性老年人高血压病肾气亏虚证的发病有关,预示血清白介素-2水平的异常变化可能是女性老年人高血压病肾气亏虚证形成的病理基础之一。

Objective ：This paper studies the relation between sex hormones related regulating factors and kidney deficiency syndrome as well as liver fire upflaming syndrome of old female hypertension, providing the pathophysiological basis. Methods ： Ac- cording to hypertension diagnosis and classification standard, TCM differentiation standard chose female hypertension of kidney de- ficiency syndrome （ 30 cases） , liver fire upflaming syndrmne （ 30 cases ） and healthy elderly women （ 30 cases ） , elisa method was used to detect IL - 2, Leptin, TNF - ct, GnRH and DHEA-S levels. Result ： The abnormal changes of sex hormones related regula- ting factors of hypertension of kidney deficiency syndrome had relations with the onset of the disease. It indicated abnormal changes of IL -2 level may be one of the pathological basis of hypertension of kidney deficiency syndrome.