三种联合化疗方案治疗晚期食管癌疗效分析

THE EFFICACIES OF 3 COMBINED CHEMOTHERAPIES IN TREATMENT OF ADVANCED ESOPHAGEAL CANCER

目的 :回顾性分析比较PF ,BMP ,ELFP三种方案治疗晚期食管癌的临床疗效和毒性。方法 :选择病理证实的晚期食管癌 71例 ,分成 3组 ,分别用上述 3种方法进行治疗。结果 :PF ,BMP ,ELFP有效率 (CR +PR)各为33% ,6 4% ,6 8.8% ;按病变部位分析 :ELFP对骨转移、原发灶、淋巴结转移、肺转移、肝转移有效率为 5 0 .0 %～10 0 .0 % ;BMP对骨转移、原发灶、肺转移、肝转移、淋巴结转移有效率为 5 0 .0 %～ 85 .7% ;PF对原发灶、淋巴结转移、肺转移有效率为 2 5 %～ 42 % ,对肝转移、骨转移无效 ;治疗后有效病例生存期为 4～ 6 7月 ,中位生存期分别为 5 ,6 ,9个月 ,1年以上生存率分别为 2 0 % ,16 % ,31.2 %。结论 :BMF ,ELFP两方案有效率相仿 ,较PF方案有效率高 ,但毒性偏大 ,应选择性应用 。

OBJECTIVE:The efficacies and toxicities of 3 combined chemotherapies, PF, BMP, and ELFP, in treatment of advanced esophageal cancer were compared. METHODS:66 patients with advanced esophageal cancers were randomly divided to receive PF, BMP, or ELFP. RESULTS:The effective rate (CR+PR) for groups PF, BMP, and ELFP was 33%, 64%, and 68.8% respectively. The median survival time for PF, BMP, and ELFP groups was 5, 6, and 9 months respectively.CONCLUSION:The effective rate in group BMP and ELFP is similar but higher than that of group PF and conversely, the toxicity in group BMP or ELFP is higher than that of group PF.