孕期补钙预防高危孕妇妊娠期高血压疾病的临床观察

Clinical observation of calcium supplementation during pregnancy in prevention of gestational hypertension

目的探讨孕期补钙对预防高危孕妇妊娠期高血压疾病和胎儿生长受限(fetal growth restriction,FGR)的效果。方法选择2009年5月至2011年4月,在深圳市光明新区人民医院门诊行产检并有妊娠期高血压疾病高危因素的孕妇162例,随机分为补钙组(86例)及对照组(76例)。补钙组自孕20～27周起口服葡萄糖酸钙片1.5g/d,连续口服至分娩,对照组未补钙。两组均在进入研究时、晚孕期和临产时检测血清钙,观察妊娠期高血压疾病及胎儿生长受限发病情况。结果补钙组晚孕期和产时血清钙高于补钙前(P<0.05);补钙组妊娠期高血压疾病和FGR发生率明显低于对照组(P<0.05)。结论孕期补钙可有效预防妊娠期高血压疾病的发生,保障胎儿健康发育。

Objective To explore the clinical effect of calcium supplementation in prevention of gestational hypertension and fetal growth restriction （FGR） for pregnant women with high risk factors. Methods The clinical data of 162 cases with gestational hypertension from Shenzhen Guangming new district people＇ s hospital from May 2009 to April 2011 were analyzed. These patients were randomly divided into calcium supplementation group （86 cases） and control group （76 cases）. Calcium supplementation group should take 1.5g calcium gluconate tablets orally per day from 20th -27th weeks of pregnancy, till the day of delivery. No calcium was given to control group. Serum calcium of the two groups should be tested at the time of research began, late pregnancy and before delivery, from which gestational hypertension and FGR could be under close observation. Results In calcium supplementation group, the value of serum calcium tested in late pregnancy and near the time of labour was higher than that before the treatment （P 〈 0. 05）, and the incidence of gestational hypertension and FGR in above group was remarkably lower than that in control group （P 〈 0. 05）. Conclusion It is confirmed that calcium supplementation has obvious effects on the prevention of gestational hypertension and FGR.