妊娠期肝内胆汁淤积症的围产儿结局探讨

Effect of intrahepatic cholestasis of pregnancy on perinatal outcomes

目的探讨妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of Pregnancy,ICP)对围产儿结局的影响及防治措施。方法回顾性分析2005～2010年ICP患者52例的临床资料,随机选取同期分娩的无ICP正常孕产妇67例(对照组)进行对比分析,比较两组围产儿结局。结果观察组胎儿窘迫、新生儿窒息、围产儿死亡及早产发生率均高于对照组,差异有统计学意义(P<0.05)。结论 ICP对围产儿结局影响极大,可引起早产、胎儿窘迫、新生儿窒息、围产儿死亡。早诊断、早治疗,加强孕产期监护,适时终止妊娠是降低其并发症的关键。

Objective To explore the effect of intrahepatic cholestasis of pregnancy （ICP） on perinatal outcomes and the preventive and therapeutic measures. Methods The clinical data of 52 cases with ICP （observation group） from the hospital from February 2005 to December 2010 were analyzed retrospectively, and 67 normal pregnant women without ICP （control group） at the same period were selected randomly, the perinatal outcomes of the two groups were compared. Results The incidences of fetal distress, neonatal asphyxia and premature delivery and perinatal mortality in observation group were significantly higher than those in control group （ P 〈 0. 05 ）. Conclusion ICP has great impact on perinatal outcomes, which can induce premature delivery, fetal distress, neonatal asphyxia and perinatal mortality. Early diagnosis, early treatment, giving intensive care during pregnancy and timely termination of pregnancy appropriately are the key points to reduce complications.