多发性硬化脑苷酯抗体检测

Detection of anticerebroside antibody in multiple sclerosis

目的 :观察多发性硬化 ( MS)患者血清及 CSF中脑苷酯抗体的分布 ,研究其在 MS发病过程中的作用。方法 :采用改良 Marcus法检测 2 0例患者血清和 CSF脑苷脂抗体的水平。结果 :本组结果表明 ,在血清和 CSF检验中 ,2 0例 MS患者 CSF和血清脑苷酯阳性率均为 70 % ;该抗体的水平在 MS组和对照组间差异有显著性意义。结论 :脑苷酯抗体也参与了 MS的发病过程。

s Objective: To observe the distribution of anticerebroside antibody in patients with multiple sclerosis and their behavior in the disease.Methods: Using Marcus method to detect anticerebroside antibodies in both serum and CSF of 20 cases.Results: It shows that the positive rate of the antibody in these patients is relative high,the antibodies'level in patient groups is significant higher than controls.Conclusion: Antibody of antiganglioside involves in the development of multiple sclerosis.