三苯氧胺治疗乳腺增生症的临床研究

Clinical study on the treatment of breast hyperplasia by tamoxifen

目的 探讨三苯氧胺 (TAM)治疗乳腺增生症的临床效果。方法 1995年 8月～1999年 10月作者采用三苯氧胺治疗乳腺增生症 182 0例 ;用乳癖消治疗乳腺增生症 90 0例 ;观察 2组用药前后黄体期血清雌二醇 (E2 )和孕酮 (P)含量 ,比较 2组临床效果和不良反应发生率。结果 血清E2 和P的恢复三苯氧胺组明显优于乳癖消组 (P <0 .0 1) ;临床效果三苯氧胺组明显优于乳癖消组 (P <0 .0 1) ;乳癖消组无不良反应 ,三苯氧胺组不良反应轻微 ,发病率低 ,停药后消失 ;随访复发率乳癖消组明显高于三苯氧胺组 (P <0 .0 1)。结论 三苯氧胺能降低血清E2 含量 ,消除疼痛及肿块 ,疗效好、不良反应少 ,是目前较为理想的治疗乳腺增生症的药物。

Objective To inquire into the clinical effect of tamoxifen for breast hyperplasia. Methods Levels of serum estradiol(E 2) and progesterone(P) during corpus lutein phase were tested before and after the drug treatment in two observed groups. Including tamoxifen group(TG) in 1?820 cases and rupixiao group(RG) in 900 cases. Additionally, comparison of the clinical effect and side effect of the drugs between the 2 groups was also studied. Results (1) TG was better than RG in the recovery of serum E 2 and P(P<0.01); (2) TG was superior to RG in clinical effects; (3) rupixiao had no side effect while tamoxifen had a low incidence of slight side effect, but it could disappear after discontinue the drug; (4) the rate of relapse was higher in RG than that in TG during the follow ups period(P<0.01). Conclusions Tamoxifen can reduce serum E 2 content, eliminate the patient's pain and the lamps. Taking tamoxifen can get an obvious curative effect without severe side effect. Tamoxifen is a satisfactory drug for breast hyperplasia at present.