骨代谢生化指标测定在妇科临床中的应用

The Biochemical Indexes of Bone Metabolism in Gynecology

目的观察骨代谢生化指标在妇女绝经前后的变化,探讨其在妇科临床中的应用价值。方法严格按照随机化原则选择绝经前后的妇女各56例,运用双能X线吸收仪测量观察者腰、髋部的骨密度(BMD),同时抽取静脉血进行骨代谢酶免疫生化指标(血骨钙素BGP、Ⅰ型前胶原羧基肽CICP、碱性磷酸酶ALP、钙Ca、磷P、及Ca/Cr和HOP/Cr比值的测定,将两组结果进行统计学分析。结果绝经后组血骨钙素低于绝经前组,差异具有统计学意义(P<0.05)、绝经后组Ⅰ型前胶原羧基肽检测结果显著高于绝经前组(P<0.01)、两组骨密度检测前后下降幅度差异无统计学意义(P>0.05)、Ca/Cr和HOP/Cr比值的测定两组间差异无统计学意义,相关性统计分析显示同组内BGP、CICP、ALP有相关性。结论表明BGP、ALP、CICP能较好地反映绝经后女性体内雌激素量下降,导致骨吸收活跃的过程,而传统上临床使用的Ca/Cr和HOP/Cr比值则不能敏感的反映出此种变化,需要进一步改进。

Objective To investigate the biochemical indices of bone metabolism in postmenopausal women.Methods Select 56 cases of pre-menopausal and post-menopausal women in strict accordance with the principle of randomization,and use dual energy X-ray absorptiometry to measure the observers＇ waists and hips bone mineral density（BMD） and measure the biochemical indexes like BGP,CICP,ALP,calcium Ca,P,and Ca/Cr and HOP/Cr ratio of the two groups.Results The BGP of two groups has a statistically significant difference（P0.05）,post-menopausal group＇sⅠ Procollagen C-peptide are significantly higher than the premenopausal group（P0.01）,the decline in bone mineral density of two groups was not statistically significant（P0.05）,Ca/Cr and HOP/Cr ratio between the two groups were no significant,BGP,CICP,the ALP related.Conclusion It shows that BGP,ALP,CICP can better reflect the post-menopausal women＇s estrogen decline,and also can lead to bone＇s resorption and active process,while traditional clinical use of Ca/Cr and HOP/Cr ratio is not sensitive to reflect such changes.