西酞普兰与文拉法辛治疗脑卒中后抑郁疗效观察

Observation on the effect of citalopram and venlafaxin in the treatment of poststroke depression

目的比较西酞普兰与文拉法辛治疗脑卒中后抑郁的临床疗效及安全性。方法将80例脑卒中后抑郁患者随机分为两组各40例,在神经内科常规治疗的基础上,研究组口服西酞普兰,对照组口服文拉法辛,均观察6周,在治疗前和治疗后第1、4、6周末分别采用汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)评定临床疗效及不良反应。结果治疗6周末,研究组总有效率为87.5%,对照组为80.0%,两组疗效比较无统计学意义(χ2=1.2085,P>0.05)。两组治疗后HAMD评分均较治疗前显著下降(P<0.01),随着治疗时间的延续均持续性下降。同期两组间HAMD评分比较无统计学意义(P>0.05)。两组不良反应均较轻。结论西酞普兰与文拉法辛治疗脑卒中后抑郁疗效显著,不良反应少,安全性高,依从性好。

Objective To explore the efficacy and safety of Citalopram and Venlafaxin in the treatment of Poststroke de- pression. Methods All 80 poststroke depression patients were randomly divided into two groups, 40 cases of each group, both groups received neuromedical routine treatment,rehabilitation,and so on; In addition,research group took orally citalopram and control group took venlafaxin for 6 weeks, clinical efficacy was assessed with the Hamilton depression scale （HAMD） and adverse reactions with the treatment emergent symptom scale （TESS） before treatment and at the end of the lst,4th and 6th week treatment. Results At the end of the 6th week,the total effective rates were 87.5% in the research and 80.0% in the control group,respectively,there was no significant difference between the two groups （χ^2 =1.2085 ,P 〉 0.05）. After treatment, the HAMD scores of both groups lowered more significantly compared with pretreatment （P 〈 0.01） and did continuously along with treatment lasting.There were no significant differences in synchronization group compar- isons （P 〉 0.05）. Reactions of both groups were mild. Conclusion Citalopram and venlafaxin has better effect,milder ad- verse reactions, higher safety and better compliance in poststroke depression.