摘要
10-羟基-2-癸烯酸(ig,100mg/kg×7-8d)能完全拮抗可的松对小鼠炭粒廓清速率的抑制作用;并可拮抗环磷酰胺对小鼠皮肤迟发性超敏反应的抑制作用,可促进环磷酰胺所致免疫功能抑制小鼠的溶血素形成;而对正常小鼠的上述免疫功能无明显影响。本文提示10-羟基-2-癸烯酸与蜂王浆的免疫药理活性有关。
10—hydroxy-2- decenoic acid (10HDA, ig, 100mg / kg×7-8d) significantly antagonized both the decrease of the clearance rate of iv charcoal particles caused by cortisione acetate and the inhibition of the delayed type hypersensitivity reaction induced by cyclophosphamide. 10-HDA remarkably facilitated the hemolysin formation in mice treated with cyclophosphamide. However, 10-HDA had no effects on the immunological functions in normal mice. It is suggested that 10-HDA may play an important role in the immunopharmacological activity of royal jelly.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1990年第3期167-169,共3页
Journal of China Pharmaceutical University
基金
国家自然科基金
关键词
10-HDA
蜂王浆
免疫功能
10-Hydroxy-2-decenoic acid
Royal jelly
Charcoal clearance rate
Delayed hypersensitivity
Hemolysin
