阿魏酸的抗炎作用

Antiinflammatory Effects of Ferulic Acid

阿魏酸对二甲苯所致的小鼠耳壳肿胀和醋酸引起的小鼠腹腔毛细血管通透性增高以及组胺引起的大鼠皮肤毛细血管通透性升高,对角叉菜胶、蛋清和甲醛所致的大鼠足跖肿胀均有明显的抑制作用;摘除双侧肾上腺后其抗炎作用仍然存在。阿魏酸显著抑制大鼠棉球肉芽组织增生、降低炎性组织中PGE_2的释放量,还能抑制角叉菜胶所致炎性渗出,但不减少渗出液中自细胞数量。此外,阿魏酸亦可降低补体旁路的溶血活性。

Ferulic acid (FA) is one of active components of Radix angelicae sinensis. FA inhibited the swelling of mouse ear induced by xylene and the increase of capillary permeability induced by acetic acid in mice and histamine in rat. FA inhibited hindpad edema induced by injection of carrageenan, fresh egg white and formaldehyde in rats. Similar effects were seen in adrenalectomized rats. FA also reduced the proliferation of granuloma caused by cotton pellet. It supressed the biosynthesis or release of prostaglandin E_2 in inflammation induced by carrageenan, but showed no effects on the migration of leucocyte. In addition, FA significantly inhibited the complement activity activated by alternative pathway. It is suggested that antiinflammatory effects of FA may be due to various ways affecting inflammatory processes and are not dependent on system of pituitary gland-adrenal.