5-氰基脲嘧啶衍生物的合成

Synthesis of 5-Cyanouracil Derivatives

合成了20个1,6-二取代-5-氰基脲嘧啶和1,3,6-三取代-5-氰基脲嘧啶类化合物。经波谱分析证实其结构。生物活性试验表明这些化合物没有PDE抑制活性。

Twenty derivatives of 1,6-disubstituted and 1,3,6-trisubstituted-5-cyanouracils were synthesized. Their structures were confirmed by spectroscopic elucidation. Experiment results of bio-activities showed that none of these compounds possessed any phosphodiesterase inhibitory activity.