芳香醛与芳香酮及芳香胺的曼尼希反应

Mannich Reactions of Aromaitic Aldehydes with Aromatic Amines and Aromatic Ketones

芳香醛、芳香酮与芳香胺在少量浓盐酸催化下于１０ ～２５ ℃直接发生曼尼希反应（ＭａｎｎｉｃｈＲｅａｃｔｉｏｎ） ，合成了４０ 个未见文献报道的曼尼希碱（Ｍａｎｎｉｃｈ Ｂａｓｅｓ） ，产率为１８．９ ％ ～９２ ．０ ％ ．考察了芳环上取代基、盐酸用量、反应温度和时间对反应的影响。

Mannich reactions of aromatic aldehydes with aromatic amines amines and aromatic ketones are performed at room temperature or slightly below in the presence of concetrated hydrochloric acid as the catalyst.Forty one new compounds are synthesized with yields of 18.9% to 92%.The effect of substituent in the ring.the amount of hydrochloric acid,reaction temperature and reaction time are systematically examined as well.