摘要
目的：评价伽玛刀放射外科治疗原发性三叉神经痛的安全性、有效性和心理状态。方法：2004年8月-2010年9月，98例经药物和其他方法治疗无效的原发性三叉神经痛患者接受伽玛刀放射外科治疗。放射剂量中位值是80Gy（75-85Gy）。采用患者自我报告疼痛的控制、生活满意度指数A（1ife satisfaction index A，LSI-A）的变化进行疗效评估。结果：治疗后89例（90．8％）患者获得随访，平均随访期35个月（13-60个月。本组病例中治愈51例（57．3％）；显效19例（21．3％）；有效11例（12．4％）；无效8例（9％），总有效率为91％；伽玛刀治疗后LSI-A总分平均值（36．25±3．87）高于治疗前（25．67±3．5）；其中67例以往未接受过手术治疗患者中62例获得随访，58例有效，总有效率为93．5％。11例患者感觉患侧面部麻胀感，1例（二次治疗者）张口轻度受限。结论：伽玛刀放射外科治疗三叉神经痛显著缓解疼痛，提高生存质量。
Objective： To evaluate the efficacy and safety of gamma knife radiosurgery in the treatment of trigeminal neuralgia （TN）. Methods： From Aug 2004 to Sep 2009, 98 patients with TN refractory to medical or other managements were treated with gamma knife radiosurgery. The median prescription dose was 80 Gy （75 - 85 Gy）. The therapeutic effects were evaluated by patient self-reports of pain control, life satisfaction index A （LSI-A）. Results： 89 patients were followed up for 35 months （13 - 60 months）. Excellent pain relief was in 51 cases （57.3%）, good pain relief was in 19 cases （21.3%）, moderate pain relief was in 11 cases （12.4%） and no pain relief was in 8 cases （9%）. The total pain relief rate was 91%. LSI-A after treatment （36.25±3.87） was higher than that before treatment （25.67±3.5）. In 67 cases never undergone operation, 62 cases were followed up and the total pain relief rate was 93.5% （58/62）. Only 11 cases complained facial numbness without physical and neurological deficit. One case had slight dysmasis. Conclusion： Gamma knife radiosurgery is effective for TN with significant pain relief and improvement of quality of life.
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2012年第5期258-260,263,共4页
Chinese Journal of Pain Medicine
关键词
伽玛刀
三叉神经痛
Gamma knife
Trigeminal neuralgia
