肝炎综合征患儿肝功能、血脂及维生素E浓度的相关性分析

Correlation analysis of the liver function,serum lipids and vitamin E concentration in infant with hepatitis

目的探讨肝炎综合征患儿血清胆红素、转氨酶、血脂及维生素E浓度的相关性。方法回顾性分析60例确诊为非胆道闭锁的肝炎综合征患儿的血清转氨酶、血脂及维生素E浓度的相关性。结果直接胆红素与总胆固醇呈正相关(r=0.314,P=0.015),与维生素E呈负相关(r=-0.435,P=0.001),丙氨酸氨基转移酶和谷氨酸氨基转移酶与维生素E呈负相关(r=-0.361,P=0.006;r=-0.421,P=0.001)。30例患儿补充维生素E后,TC、TG、TBIL及DBIL水平均显著降低(P<0.05或P<0.01)。结论补充维生素E可保护肝细胞膜,辅助改善婴儿肝炎综合征患儿的肝功能,进而促进胆汁排泄,降低胆红素和血脂水平。

Objective To discuss the correlation of the liver function,serum lipids and vitamin E concentration in infant with hepatitis.Methods Retrospective analysed the correlation of the liver function,serum lipids and vitamin E concentration in infant with hepatitis diagnosed with non-biliary atresia.Results DBIL and TC had the clearly positive correlation（r=0.314,P=0.015）,DBIL and vitamin E had a clearly negative correlation（r=-0.435,P=0.001）,ALT,AST and vitamin E showed a significant negative correlation（r=-0.361,P=0.006;r=-0.421,P=0.001）.30 cases children,after supplying vitamin E,TC,TG,TBIL and DBIL were significantly lower（P〈0.05 or P〈0.01）.Conclusion Supplying vitamin E can protect the liver cell membrane,improve the liver function of infant with hepatitis syndrome,thus contribut to biliary excretion,reduce bilirubin and serum lipids.