正交试验法优选平脂胶囊制备工艺

Preparation process of optimizing Pingzhi capsules with orthogonal test

:目的 用正交试验研究平脂胶囊制备工艺 .方法 选择三因素三水平正交试验 ,以出膏率和芍药甙含量为指标 ,用HPL C法测定煎煮稠膏中芍药甙含量 .结果 9份试验平均出干膏率 2 3.3% ,芍药甙平均含量 0 .6 3% ,平均综合分 6 8.8,煎煮时间对工艺影响显著 (P<0 .0 5 ) ,最佳制备工艺是煎煮 2次 ,每次 2 h,加水 5倍量 .结论 双指标多因素正交试验优化的中药复方制剂制备工艺经 3批扩大 1 1 4 .8倍中试 ,重现性好 ,结果稳定 。

AIM To study the preparation process of Pingzhi capsules with orthogonal test. METHODS The content of paeoniflorin in the paste decocted is assayed with HPLC method, using orthogonal test with three factors and three levels and taking the rate of paste and the content of paeoniflorin as the standards. RESULTS The average paste rate of nine tests was 23.3%, the average content of paeoniforin in nine tests was 0.63% and the average total score was 68 8. The decocted time significantly affected preparation process ( P <0.05). The optimum extraction of Pingzhi capsules was: herbs water decocted with 5 times water, decocted two times, and two hours each time (5 mg·g -1 herbs). CONCLUSION The preparation process of complex prescription of herbs with double standard and multi factor orthogonal test has good reproduction and stability to guarantee the effects of the medicine.