神经精神量表对简明智能精神状况检查量表分值的预测作用分析

Neuropsychiatric Inventory in prediction of Mini-Mental State Examination scores

目的 检验神经精神量表（Neuropsychiatric Inventory,NPI）对简明智能精神状况检查量表（Mini-Mental State Examination,MMSE）分值的预测作用.方法 对老年痴呆科住院的164例患者进行NPI和MMSE测试,对其中符合阿尔茨海默病（Alzheimer＇s dementia,AD）、血管性痴呆（Vascular dementia,VD）和轻度认知损害（Mild Cognitive Impairment,MCI）的139例进行分析.以NPI总分为自变量,MMSE总分为因变量,诊断类型、性别、年龄和文化程度等4项为协变量进行多元线性回归分析NPI总分对MMSE总分的预测作用.结果 在考虑协变量对MMSE总分的影响后,NPI总分对MMSE总分的标准回归系数β为-0.314（P＜0.01）.结论 NPI对MMSE有独立的预测作用,其预测作用不受痴呆类型、年龄、性别和文化程度的影响.

Objective To assess the predictive value of Neuropsychiatric Inventory （NPI） for the scores of Mini-Mental State Examination （MMSE）. Methods NPI and MMSE were tested in 139 patients with AIzheimer＇s dementia （AD）, Vascular de- mentia （VD） or Mild Cognitive Impairment （MCI）who were admitted to Department of Dementia, Zhejiang Hospital within 9 months. Multiple linear regression analyses were conducted where NPI total scores were treated as the independent variable, MMSE total scores as the dependent variable, and diagnosis, gender, age and educational levels as the covariates. Results Adjusted for those covariates, the standard regression coefficient （β） was -0.314 （P〈0.01）. Conclusion NPI has an independent predictive effect on MMSE and this effect is not confounded by those considered covariates.