RON基因在非小细胞肺癌中的表达及其临床意义

Expression of RON gene in non-small cell lung cancer and its clinical significance

目的 研究RON基因在人非小细胞肺癌组织中的表达水平及其临床意义.方法 收集2007年1月至 2008年12月手术的肺腺癌及鳞癌组织标本共96例,应用Envision二步法检测96例肺腺鳞癌中RON蛋白的表达情况,统计分析非小细胞肺癌组织中RON表达与临床病理相关因素的关系.另外检测20例正常肺组织中RON蛋白的表达情况,比较RON在肺癌组织和正常组织中的表达情况.结果 RON在肺癌组织中表达明显（63/96,66%）,而正常肺组织中几乎无表达（1/20,5%）.在肺癌组织中,RON在肺腺癌及鳞癌中都有不同程度的表达,两组相比RON的表达差异具有统计学意义,腺癌标本中RON表达明显高于鳞癌（P＜0.05）;不同分化程度的肺腺癌相比,RON的表达也有差异,低分化的肺腺癌明显高于中分化的腺癌和高分化的腺癌（P＜0.05 ）,而有淋巴结转移者及晚期组患者组织中RON的表达亦明显高于无淋巴结转移者及早期组患者.结论 RON基因可能在肺癌的发生、发展过程中起着重要作用,提示其可作为肺癌一种新的预后判断指标和治疗靶点.

Objective To investigate the expression of RON gene in non-small cell lung cancer （NSCLC） and its clinical significance. Methods The expression of R^N gene in 90 tissue specimens of NSCLC and 20 specimens of normal lung tis- sues was detected by immunohistochemical Envision method, the relationship of RON expression with clinicopathology and prognosis of disease was analyzed. Results The positive expression rates of RON gene were 65.6%（63/96） and 5.0% （1/20）in lung cancer and in normal lung tissues respectively （P〈0.05）. The expression of RQN gene was significantly correlated with pathologic type, differentiation, stage and lymph node metastasis of lung cancer and not correlated with sex and ages of patients. Conclusion RON gene may be associated with the development and progress of lung cancer,which might be used as a new prognostic indicator for patients with lung cancer,