单磷酸阿糖腺苷治疗慢性乙型肝炎临床研究

CLINICAL STUDY ON ARABINOSYLADENOSINE MONOPHOSPHATE IN THE TREATMENT OF CHRONIC HEPATITIS B

目的研究单磷酸阿糖腺苷治疗慢性乙型肝炎的临床疗效。方法选择189例慢性乙型肝炎患者,分别单独应用单磷酸阿糖腺苷联合胸腺肽、乙肝疫苗、阿昔洛韦、自体LAK细胞回输5个治疗组,并以抗乙肝免疫核糖核酸作对照,评估各组肝功能和HBV复制近、远期疗效。结果不论单独应用单磷酸阿糖腺苷或联合其它药物及疗法治疗慢性乙型肝炎,ALT复常率、HBeAg、HBVDNA转阴率近、远期疗效均高于对照组(P<0.01),但以联合胸腺肽、自体LAK细胞回输治疗组效果最佳。结论肯定了单磷酸阿糖腺苷治疗慢性乙型肝炎降酶、抗乙肝病毒的效果。

ObjectiveTo evaluate the clinical efficacy of arabinosyladenosine monophosphate (Ara Amp) on chronic hepatitis B patients.MethodsSelected 189 cases with chronic hepatitis B were divided into five groups:Ara Amp only,Ara Amp with thymosin,hepatitis B vaccine,aciclovir,LAK cell self transfuion.And an Anti HBV RNA group was established as a control group.ResultsNo matter only Ara Amp or combined with other drugs in the treatment,ALT recovery,HBeAg and HBV DNA negative transformed rates were higher than those of the control group both in short term and in long term (P< 0.01 ).But the efficacy appeared to be best in the groups of Ara Amp with thymosin and LAK cell self transfused.ConclusionIt proved Ara Amp efficacy in the treatment of chrontic hepatitis B for decreasing ALT and fighting against HBV,but that in the combined groups is better than that of the control one.