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p53和c-erbB-2型在卵巢上皮性癌中的表达及其临床意义 被引量：2

SIGNIFICANCE OF EXPRESSION OF p 53 AND c-erbB-2 IN OVARIAN EPITHELIAL CARCINOMA
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摘要 目的探讨卵巢上皮性癌(简称卵巢癌)p53和cerbB2表达的临床意义。方法用免疫组织化学法检测p53和cerbB2,结合临床病理及肿瘤的生物学行为进行分析。结果p53在高分化卵巢癌中的表达频率显著低于中、低分化癌,p53表达阳性组的卵巢癌对化疗不敏感,其预后亦明显劣于阴性组卵巢癌。卵巢癌的cerbB2表达与临床期别、组织学类型和分级、残余瘤大小、化疗疗效和预后均无显著相关性。结论p53是评价卵巢癌化疗耐药性和预后的可靠指标。 ObjectiveTo explore the clinical significance of p 53 and c erbB 2 expression in ovarian epithelial carcinoma.MethodsThe expression of p 53 and c erbB 2 were examined by immunohistochemical method,and the relationship between the expression of two factors and clinicopathologic features resistant to chemotherapy and prognosis were analyzed.ResultsThe expression p 53 had significant lower frequency in well differentiated ovarian tumor than that in medium and poor differentiated one.p 53 positive tumors related with drug resistance and poor prognosis significantly.The expression of c erbB 2 was not associated with clinical stage,histologic type,grade, residual tumor,chemotherapy and prognosis.Conclusionp 53 expression in ovarian cancer is related to drug resistance,and it is a useful prognostic index.
作者 范金兰 于会敏 冯秋红 宋俊芬
机构地区 河北医科大学第四医院妇产科
出处 《河北医科大学学报》 CAS 2000年第2期87-89,共3页 Journal of Hebei Medical University
关键词 卵巢肿瘤 P53蛋白质 上皮性癌 代谢 药物疗法 ovarian neoplasms/metab protein p 53 /metab oncogene/immunol histological technics ovarian neoplasms/drug ther drug tolerance
分类号 R737.31 [医药卫生—肿瘤]
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共引文献157

同被引文献15

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河北医科大学学报
2000年 第2期

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