苯扎贝特对poloxamer 407诱导的昆明小鼠血脂的影响

Hypolipidemic effects of Bezafibrate on poloxamer 407-induced hyperlipidemic Kunming mouse model

【目的】研究苯扎贝特对poloxamer 407(P407)诱导的新型高血脂小鼠的血脂影响。【方法】昆明小鼠给予苯扎贝特(50或100 mg/kg)灌胃,连续3 d,末次给药1 h后,给予动物腹腔注射P407,0.3 g/kg,于注射后的4、24及48 h,取血测定甘油三酯和胆固醇含量,注射P407后24 h的血样同时测定高密度脂蛋白-胆固醇的含量。【结果】在造模前给予苯扎贝特处理,能明显降低高血脂动物的血清甘油三酯和胆固醇水平,且剂量关系明显,此作用可维持至造模后的48 h。高血脂造模后的24 h,苯扎贝特能明显升高模型动物的血清高密度脂蛋白-胆固醇水平。【结论】苯扎贝特对于P407诱导的高血脂昆明小鼠模型具有降脂作用,此模型可用于贝特类药物的研究。

[Objective]To study the effect of Bezafibrate on poloxamer 407-induced new hyperlipidemic mouse model. [Methods] Before a bolus of poloxamer 407 （0.3 g/kg） was intraperitoneally dosed, Kunming mice were pretreated orally with Bezafibrate （50 or 100mg/kg） for 3 days. Blood triacylg｜ycerol （TG） and cholesterol （CHO） were measured at 0, 4, 24 and 48 h after the poloxamer 407 injection, and the blood HDL-CHO level of Time2＋, were measured. [Results] Poloxamer407 injection caused hyperlipidemia in Kunming mice. Bezafibrate decreased dose-dependently blood TG and CHO, and this hypoipidemic effect lasted up to 48 h after injection. Moreover, Bezafibrate increased blood HDL-CHO in poloxamer 407 induced hyperlipidemic mice. [Conclusions] Bezafibrate could have a hypolipidemic effects in poloxamer 407induced hyperlipidemic Kuonming mice. This animal model may be used to evaluate the lipid-lowering effects of statin drugs.