人工虫草多糖对小鼠免疫功能的影响

Effects of Polysaccharides from Cultured Cordyceps sinensis on Murine Immunologic Function

采用碳粒廓清法、二硝基氟苯诱导小鼠迟发型变态反应试验法及溶血素试验法 ,观察人工虫草多糖对非特异性和特异性免疫功能的影响。结果表明人工虫草胞内及胞外多糖能显著地增加碳粒廓清指数K及吞噬指数α ,增强单核巨噬细胞的吞噬功能 ;胞内多糖并能显著地增加小鼠耳肿胀度 ,增强二硝基氟苯诱导的小鼠迟发型变态反应 ,提高溶血素水平 。

Carbon clearance test, hemolysin test and dinitrofluorobenzene induced delayed type hypersensitivity test(DTH)were used to evaluate the immunomodulating effects of polysaccharides from cultural mycelium and fluid of Cordyceps sinensis on non specific and specific immunologic function. Results showed that both PCM and PCF could increase the index of K, α and the viscus index of spleen and thymus in carbon clearance test. It was also found that PCM enhanced murine ear swelling and hemolysin level, suggesting that PCM could improve the cellular and humoral immunologic function.