慢性阻塞性肺疾病患者血浆及痰中P物质变化及其与肺功能关系的研究

Elevated substance P content in sputum and plasma in patients with COPD and its relationship with FEV 1/FVC

目的 探讨P物质 (SP)在慢性阻塞性肺疾病 (COPD)发病中的作用及其与肺功能的关系。方法 用放射免疫分析法观察 2 0名健康受试者 ,2 0例COPD患者血浆及痰中P物质的含量 ,同时检测肺功能 ,并分析血浆及痰中P物质的含量与一秒钟用力呼气容积占用力肺活量比值 (FEV1/FVC)的相关关系。结果 COPD患者血浆SP浓度 (8 6± 3 9)pmol/L明显高于对照组 (3 8± 2 0 )pmol/L(P <0 0 5 ) ;COPD患者痰SP浓度 (5 7 3± 14 5 )pmol/L明显高于对照组 (5 9± 2 6 )pmol/L(P <0 0 1)。COPD患者血浆SP浓度与FEV1/FVC呈负相关 (r=- 0 5 91,P <0 0 5 ) ;痰SP浓度与FEV1/FVC呈负相关 (r=- 0 6 42 ,P <0 0 5 )。

Objective To investigate the role of substance P(SP) of the nonadrenergic system within airways in the pathogenesis of COPD, and analyze the relationship between level of SP and FEV 1/FVC in COPD patients. Method SP concentration in sputum and plasma in 20 patients with COPD and 20 normal volunteers was examined and was measured by radioimmunoassay Results The sputum SP concentration was significantly higher in patients with COPD (57 3±14 5) pmol/L than that in normal volunteers(5 9±2 6) pmol/L, P <0 01, the plasma SP concentration was significantly higher in COPD patients (8 6±3 9) pmol/L than that in normal volunteers (3 8±2 0 ) pmol/L, P <0 05 The plasma and sputum SP concentration correlated with FEV 1/FVC in COPD patients ( r =-0 591, r =-0 642, P <0 05) Conclusion These data suggest that neurogenic inflammation may be involved in the airway inflammation process and subsequent airway narrowing in COPD