喉角化症中EGFR的表达及与恶变的关系

Expression of EGFR in keratosis of laryngeal and the correlation with malignant phenotype

目的 :观察表皮生长因子受体 (EGFR)在喉角化症中的表达 ,探讨喉角化症的转归和预后。方法 :利用免疫组化 ABC法检测 32例喉角化症患者组织中 EGFR的表达情况。结果 :在轻、中、重度非典型增生中 ,EGFR表达分别为 12 .5 %、2 2 .5 %和 47.8%。重度非典型增生的 EGFR表达与轻、中度非典型增生比较有显著性差异 (P<0 .0 5 )。结论

Objective:To evaluate the roles of EGFR expression in laryngeal keratosis.Method:The ABC immunohistochemical method was performed to investigate the expression of EGFR in 32 cases of laryngeal keratosis tissue.Result:The EGFR indices in light、moderate and serious non typical hyperplasis were 12.5 %, 22.5 % and 47.8 % respectively.There were significant differences between heavy with light and middle non typical hyperplasis (P< 0.05 ).Conclusion:The EGFR might play some role in the process of carcinogenesis of laryngeal keratosis,and be as an useful marker for the assessment of the behavior and prognosis in the laryngeal peremalignant lesions keratosis.