血清降钙素原对老年人感染性疾病的诊断价值

Diagnostic Value of Serum Procalcitonin in the Elderly with Infectious Diseases

目的评价血清降钙素原（PCT）对老年人感染性疾病的诊断价值。方法收集在武汉大学人民医院诊治的老年患者的血清标本，行降钙素原检测，并与微生物培养结果进行比较分析。结果感染组PCT浓度为（4．48±13．09）ng／ml，高于非感染组（0．07土0．02）ng／ml（t=5．31，P〈0．05）。细菌感染组、真菌感染组、混合感染组PCT浓度分别为（9．97土21．65）ng／ml，（5．92±8．82）ng／ml，（14．13士21．41）ng／ml，三组问PCT浓度差异无统计学意义（t=-1．08，P=0．284；t=-0．80，P=0．425；t=-2．14，P=0．064），若以血清PCT≥0．115ng／ml为诊断感染的阳性临界值，其敏感度、特异度分别为77．80％，93．80％。结论血清PCT检测敏感度高于培养，对老年感染患者具有重要的早期、快速诊断价值。

Objeetive To evaluate the diagnostic value of serum procalcitonin （PCT） for elderly with infectious diseases. Methods The elderly who were diagnosed and treated in wuhan university of People＇s hospital were enrolled and their serum PCT was detected, then compared with the culture results of pathogenic microorganism. Results The concentration of serum PCT in infected group was （4. 48± 13.09）ng/ml, which was higher than it in non-infected group （0. 07 ± 0. 02） （t= 5.31, P 〈0. 05）. The concentration of bacterial group, fungal group and mixed group was （9.97 ±21.65）ng/ml, （5.92 ± 8. 82）ng/ ml and （14.13±21.41）ng/ml respectively. There were no statistical differences among those groups （t= 1.08, P=0. 284 ~ t =-0. 80, P=0. 425;t=- 2.14, P= 0. 064）. If 0. 115 ng/ml was considered as the cut-off value, its sensitivity, specificity was 77.80%,93. 805/0 respectively. Conlusion The sensitivity of PCT was higher than cultivation,which has a significant early diagnostic value for infection in the elderly.