69例肺结核患者血清胆碱酯酶活性变化分析

Analysis of Serum Cholinesterase Actiity Change in Tuberculosis Patients

目的探讨血清胆碱酯酶（cHE）活性的检测在肺结核患者中的意义。方法选择2009年11月～2010年12月以来于西安市结核病医院进行治疗的肺结核患者69例，另外选择50例正常健康人群进行时照，测定两组患者血清胆碱酯酶的活性水平，比较二者之间的差异。结果69例肺结核患者的血清胆碱酯酶活性水平与正常对照组之间存在一定差异。其中，69例肺结核患者血清胆碱酯酶平均活性水平为4233士653．2U／L，50例健康对照组为6196士716．9U／L，肺结核组血清胆碱酯酶活性水平显著低于健康对照组，二者差异极显著（t=39．6，P〈O．01）。结论血清胆碱酯酶可以在一定程度上反应患者的肝脏实质损伤状况，为肺结核患者的实验室诊断与临床用药提供一定的临床依据。

Objective To investigate significance of detecting the serum cholinesterase （CHE） activity in the TB, patients. Methods Selected 69 patients in the Tuberculosis Hospital of Xi＇an City since the tuberculosis patients treated,in Novem- ber 2009 to December 2010. Another choosed 50 cases of normal healthy crowd to compare. Determined enzyme cholinester- ase activity levels,compared the difference between the two. Results There was some difference about serum cholinesterase actiity levels between 69 patients with tuberculosis and the normal control group. Among them, 69 patients with tuberculo- sis, their average serum cholinesterase activity level was 4 233± 653.2 U/L, but 50 cases of healthy control group was 6 196±716.9U/L. Serum cholinesterase activity level of tuberculosis group was significantly below healthy control group and both had extremely significant difference （P〈0. 01）. Conclusion To a certain extent, serum cholinesterase can responses patients with hepatic essence damage status. For tuberculosis patients, serum cholinesterase can provide certain clinical evi- dence in laboratory diagnosis and clinical medicatione.