西安市灞桥区某村成人乙型和丙型肝炎感染流行病学调查

Epidemiological Investigation of HBV and HCV Infection among Adults in a Village of Baqiao in Xi＇an

目的了解西安地区成人乙型和丙型病毒性肝炎感染现状，以建立有效的防治措施。方法采用EI．ISA法对西安市灞桥区某村488例16～76岁自愿参加西京医院研究的村民进行问卷调查并采血分离血清进行HBsAg和抗-HCV抗体的检测。同时对村民进行血清DBII，，ALT，Alb，A／G及AST／ALT栓-蒯。结果①抗-HCV阳性率随年龄的增长显著增加（χ^2=32．64，P〈o．01），感染高峰集中在46～66岁；HBsAg阳性率随年龄的增长呈现下降趋势，但无统计学意义。②抗-HCV阳性率为15．57％，女性阳性率显著高于男性（χ^2=4．53，P〈0．05）；HBsAg阳性率6．97％，男性阳性率显著高于女性（χ^2=4．75，P＜0．05）；女性村民中Anti—HCV阳性率显著高于HBsAg阳性率（χ^2=8．10，P＜0．01）。③抗-HCV，HBsAg阳性组DBII．，ALT，AST较阴性组均有显著升高，而Alb，A／G则显著下降（P＜0．05）；抗-HCV阳性组Alb，A／G显著低于HBsAg阳性组（P＜O．05），而AST／ALT则显著高于HBsAg阳性组（P＜d0．05）。结论该村成人村民中存在较高的抗-HCV阳性捡出率；抗-HCV阳性率随年龄的增长显著增加，感染高峰集中在46～66岁，女性高于男性；HBsAg阳性者以青壮年男性为主；该村H13sAg阳性者呈活动性感染。抗-HCV阳性者在非法卖血感染HCV病毒后病情呈慢性化。

Objective To investigate the situation of HBV and HCV infection in a local village, in order to take measures to control Ht3V and HCV. Methods 488 Villagers in 16-76 years old were selected. Blood specimen were collected and serum were isolated. Anti-HCV,HBsAg,blood serum DBIL,ALT,Alb,A/G and AST/ALT were analyzed. Results ①The posi- tive rate of anti-HCV increased significantly with age（χ^2 =32. 64, P〈0. 01） and gathered between 46 and 66 years old. The positive rate of HBsAg decreased with age and gathered between 26 and 46 years old, but there was no statistical signifi- cance. ②The positive rate of anti-HCV was 15.57% and the positive rate of femal was significantly higher than male（χ^2 =4.53, P〈0.05）. The positive rate of HBsAg was 6.97% and the positive rate of male was significantly higher than femal（χ^2 =4.75, P〈0. 05）. Meanwhile,in the female cases the positive rate of Anti-HCV was significantly higher than that of HB- sAg（χ^2 =8. 10, P〈0. 01）. QThe contents of DBIL, ALT and AST were significantly higher in the positive group of Anti- HCV and HBsAg than that in negative group. However, the contents of Alb and A/G were significantly lower（P〈0.05） . Compared with the positive group of HBsAg, the contents of Alb and A/G decreased but that of AST/ALT increased in the positive group of anti-HCV（P〈0. 05）. Conclusion There was a high detection rate of anti-HCV among adults in the village of Baqiao. The positive rate of anti-HCV increased significantly with age and gathered between 46 and 66 years old. However, the HBsAg positive individuals mainly were the mail youths of the village. The HBsAg positive infection occurred reactively, meanwhile and the pathogenetic condition of the villagers advanced into chronic phase after the infection of HCV during the long-term unlawful blood donation.