摘要
粉防已甲素和乙素对L7712和S180癌细胞DNA合成的ID_(50)分别为2.6,3.5和27.5,24.5mg/L;它们对L7712细胞DNA合成的抑制是由DNA复制模板受到损伤而引起的。它们对两种癌细胞DNA和RNA的合成有很强的抑制作用,对蛋白质合成的抑制作用较弱。两种药物对癌细胞抑制程度和作用方式相似。
The 50% inhibition doses ( ID50 ) of tetrandrine and demethyl tetrandrine on DNA synthesis in L7712 and Sl80 cells are 2.6, 3 .5mg/ L and 27.5, 24.5mg/L respectively. The DNA synthesis inhibition is likely due to DNA template damage caused by both natural products. The inhibition of DNA, RNA and protein syntheses by tetrandrine or demethyl tetrandrine increased with incubating time. The inhibiting activities of two natural products on DNA and RNA synthesis are s-tronger than on protein. There are no differences either in inhibiting activity or in inhibiting mechanism between two natural products.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1990年第1期53-55,共3页
Chinese Pharmacological Bulletin
基金
中国科学院科学基金
关键词
粉防已甲素
粉防已乙素
癌细胞
Tetrandrine
Demethyl tetrandrine
Leukemia 7712
Sarcoma 180
DNA
RNA
Protein syntheses