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间尼索地平与尼索地平对清醒兔血流动力学和局部血流量的影响 被引量:8

EFFECTS OF M-NISOLDIPINE AND NISOLDIPINE ON THE HEMODYNAMICS AND REGIONAL BLOOD FLOW IN CONSCIOUS RABBITS
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摘要 应用放射性生物微球技术观察间尼索地平(m-Nis)和尼索地平(Nis)对清醒兔血流动力学和局部血流量的影响。m-Nis 1μg/kg·min^(-1)×10min iv显著增加清醒兔CO、CI、SV和LVSW;等剂量Nis增加CO及CI不显著;两药对清醒兔MABP、HR和脑、心、肾、脾等局部血流量影响相似,对这些器官的血流分布及心输出量分布无明显影响。 m-Nisoldipine ( m-Nis ) , isobutyl methyl 1 , 4-dihydro - 2, 6-dimethyl-4-( 3-nitrophenyl )-3 , 5-pyridine dicarboxylate, is a new calcium antagonist. Its effects on hemodynamics and regional blood flow as well as the distribution of cardiac output were evaluated in comparison with Nis with radio-biomicrospheres in conscious rabbits. ( 1 ) m-Nis ( 1 μg/kg · min-1 × 10 min, iv ) increased cardiac output and cardiac index significantly (P<0.05), while Nis at the same dose only slightly increased these parameters (P>0.05) ; ( 2 ) m-Nis increased stroke volume and left ventricular systolic work ( per beat ) while Nis slightly increased the former and decreased the later, and these differences were statistically significant (P<0.05) . ( 3 ) Both compounds were equally effective in decreasing mean arterial blood p-ressure, increasing regional blood flow and decreasing relative blood flow resistance of the brain, the heart and the spleen.
出处 《中国药理学通报》 CAS CSCD 北大核心 1990年第2期114-117,共4页 Chinese Pharmacological Bulletin
关键词 间尼索地平 尼索地平 血流动力学 m-nisoldipine Nisoldipine Hemodynamics Regional blood flow Radio-biomicrospheres Conscious rabbits
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参考文献2

  • 1吕志勤.急性低氧与间断低氧适应对家兔局部血流分布的影响[J]中国应用生理学杂志,1987(01).
  • 2胡燕,胡国新,方达超,江明性.清醒大鼠血流动力学的实验方法[J]中国药理学通报,1986(05).

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