摘要
用大鼠杏仁核点燃模型研究了抗痫灵的抗癫痫作用。每日1次电刺激杏仁基底外侧核可在第15d产生点燃效应的5期反应,刺激后放电显著延长。抗痫灵在未产生中枢镇静的剂量就能抑制点燃效应的5期反应,ED_(50)为84.7mg/kg,对刺激后放电影响较少。丙戊酸钠抑制5期反应作用较强,并能显著缩短刺激后放电时程。实验表明抗痫灵具有对抗慢性杏仁核点燃效应的作用。
The effect of antiepilepsirine, a derivative of piperine, on the rat amygdala kindled seizures was studied. An average of daily consecutive 15 stimulations was needed to reach the first stage 5 seizures, at which the rats showed behavioral convulsions and electroencephalogra-phic abnormalities. Antiepilepsirine ip 2 h before stimulation at the doses that did not show obvious sedation suppressed the stage 5 seizures with the ED50 of 84.7mg/kg and exhibited insignificant shortening of afterdischarge duration. Sodium valproate effectively protected against stage 5 seizures and shortened the afterdischarge duration. Present data suggest the chronic antiepileptic property of antiepilepsirine in rat amygdala kindling model.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1990年第2期87-90,共4页
Chinese Pharmacological Bulletin
基金
国家教委青年教师和国家自然科学基金资助项目
关键词
抗痫灵
杏仁核
占燃效应
癫痫
Epilepsy
Kindling model
Basolateral amygdaloid
Afterdischarge
Antiepilepsirine
Sodium valproate
