肌注复方庚炔诺酮避孕针后唾液及血清中炔诺酮浓度

NET LEVELS IN SALIVA AND SERUM AFTER MULTIPLE INJECTIONS OF NET-OEN PLUS EV AND THEIR RELATION

本文对10名使用复方庚炔诺酮(NET—OEN/EV)针剂妇女,用RIA法作了唾液和血清NET浓度的测定,并对其动力学过程进行了为期12个月的自身对照观察。结果表明,在第1、第6和第12治疗周期:唾液和血清NET浓度呈平行变化,两者浓度相差20～50倍;达峰时间均为5d;唾液与血清NET浓度线性回归分析呈显著性相关。

Since saliva has been widely used as a fluid for monitoring drug concentrations, both saliva and serum samples were collected after multiple injections of Norethisterone Enanthate ( NET-OEN ) 50mg and Estradiol Valerate ( EV ) 5mg from 10 women. The concentration of NET in saliva was measured by RIA using diluted antisera working solution and serum NET level was measured by RIA according to our lab. regular method. The assay was running very well. The phar- macokinetics of NET in saliva were observed from the data obtained. The time to reach peak levels in saliva was 5d after injection, which was similar to the Tmax of NET in blood. Mean peak values of NET in saliva were about 220, 218, and 158 ng/L which were almost 1/30 to 1/40 of the Cmax of NET in serum (8506, 6888, and 5619 ng/L) for 1st, 6th, and 12th injections. The concentration of NET in saliva showed to be very closely related to the serum NET concentration in the same subject, and the correlation coefficients were 0.86, 0.83, and 0.80 ( P<0.001 ) in 1st, 6th, and 12th cycles respectively.